Data from a cohort of one million patients with chronic limb-threatening ischaemia (CLTI) were recently presented as late-breaking clinical research at the Society for Cardiovascular Angiography & Interventions (SCAI) 2023 Scientific Sessions (18–20 May, Phoenix, USA). Using data from Medicare, the cohort, CLIPPER (Chronic limb threatening ischaemia process performance), found one out of six patients with CLTI died within their first year of diagnosis and 50% survived at five years.
Using data from Medicare, the CLIPPER cohort was created to develop and test process measures for CLTI, which could ultimately be used to measure and improve quality of care.
Using inpatient and outpatient claims data from patients with fee-for-service Medicare from 2010 to 2019, a coding algorithm was used to identify patients with CLTI. To qualify for a CLTI diagnosis, patients had either 1) one diagnostic code for peripheral arterial disease and one diagnostic code for ulceration, infection, or gangrene on the same inpatient or outpatient claim, or 2) one CLTI-specific diagnostic code, as well as a procedure code indicating arterial vascular testing within six months before or after the qualifying CLTI diagnostic code(s).
The cohort comprised 1,130,065 patients diagnosed with CLTI between 2010 and 2019. Mean age of the cohort was 75±5.8 years; 48.4% were women and 14.6% were Black. Within 30 days of CLTI diagnosis, 20.4% of patients underwent percutaneous or surgical revascularisation. Within six months, 3.3% of patients underwent major amputation; 16.7% of patients died at one-year follow-up and 50.3% at five-year follow-up.
“CLTI is an incredibly deadly disease if not treated quickly after diagnosis, but we know very little about how hospitals perform with respect to treatment,” said lead author Alexander Fanaroff (University of Pennsylvania, Philadelphia, USA). “Comprehensive process measures are needed for patients in order to advance care and improve the chance of survival. Our hope is that this study is a first step toward developing better process measures.”
The authors note they plan for the CLIPPER data to be used for future studies on CLTI, including developing process measures that can be captured from administrative claims data, and measuring their association with limb outcomes and corresponding racial, ethnic, socioeconomic, gender-based, and geographic variability.