Bariatric arterial embolization emerges as less invasive treatment for morbidly obese individuals


A safe, new, minimally invasive treatment, developed by interventional radiologists, led to sustained weight loss in severely obese people, according to research presented at the Society of Interventional Radiology’s 2016 Annual Scientific Meeting.

Researchers said the treatment could offer individuals a viable, safe alternative to surgical weight-loss treatments. Researchers designed the BEAT Obesity (Bariatric embolization of arteries for the treatment of obesity) pilot clinical trial to evaluate the safety and effectiveness of bariatric arterial embolization as a minimally invasive, image-guided treatment option for obese people struggling with weight loss.

“These early results demonstrate that bariatric arterial embolization appears to be effective in helping patients lose a significant amount of weight in the short and intermediate term,” said Clifford Weiss, associate professor of Radiology and Radiological Science and director of Interventional Radiology Research at the Johns Hopkins University School of Medicine, Baltimore, USA.

“Compared to a surgical gastric bypass procedure, bariatric arterial embolization is significantly less invasive and has a much shorter recovery time.” It targets the fundus of the stomach which produces the vast majority of the body’s most powerful hunger hormone, called ghrelin. Bariatric arterial embolization is performed exclusively by interventional radiologists, who use image guidance and catheters to access the specific blood vessels to this portion of the stomach through a small nick in the skin at either the groin or wrist. The physician then injects microscopic beads to decrease blood flow to that portion of the stomach, thereby suppressing some of the body’s hunger signals, leading to reduced appetite and weight loss.

Weiss and his team enrolled seven severely obese, but otherwise-healthy, adults with a body mass index (BMI) ranging from 40 to 60, far above the obesity threshold level of BMI of 30. The researchers worked collaboratively with a multidisciplinary team that included weight loss physicians, hormone specialists, gastroenterologists and surgeons. All study participants were enrolled in the Johns Hopkins Weight Management Center so they could understand and implement critical lifestyle and diet changes before and after the procedure.

After the treatment, researchers tracked the subjects’ weight loss, ghrelin levels, hunger and satiety assessments, quality-of-life (using surveys), blood pressure, and adverse events at one-, three- and six-month marks.

In these first seven patients, bariatric embolization was safe, with no major adverse events. All patients demonstrated weight loss and dramatic hunger reduction levels after the procedure. Ghrelin levels trended down, and quality-of-life scores improved. In the first month following the procedure, participants had an average excess-weight loss (the percentage loss of the pounds above the patient’s ideal body weight) of 5.9% percent. After six months, the participants’ excess-weight loss increased to an average of 13.3%.

“Obesity is a highly prevalent, detrimental and costly disease in the USA and abroad,” Weiss said. “Currently, interventions to treat this condition include behavioural modifications, diet and exercise, medications, and surgery. We are excited about the promise of bariatric arterial embolization as another tool for healthcare providers to offer patients in the effort to curb this epidemic. As this study expands and includes more patients, we will be able to gain more insight into the efficacy of the treatment and the role interventional radiology can play in the critical battle against obesity.”

Weiss stressed that this research is still in its early stages. Now that the safety of this procedure has been demonstrated, more clinical trials are needed to evaluate larger numbers of patients to determine the treatment’s efficacy and durability over time.