The Society of Interventional Radiology Foundation has released a statement announcing that the NIH-sponsored ATTRACT (Acute venous thrombosis: thrombus removal with adjunctive catheter-directed thrombolysis study) has completed accrual of its originally planned cohort of 692 patients.
Suresh Vedantham, professor of Radiology, Interventional Radiology Section, Washington University School of Medicine in St Louis, USA, and principal investigator of the trial made the announcement on behalf of its steering committee. As stated on the SIR Foundation webpage: “ATTRACT, which enrolled patients in 56 hospitals, will determine if the use of pharmacomechanical catheter-directed thrombolysis in patients with acute proximal deep vein thrombosis prevents the post-thrombotic syndrome and improves quality of life.”
“ATTRACT is more than three times the size of the only other multicentre randomised controlled trial of deep vein thrombosis thrombolysis. Combined with its strong methodological design and rigorous conduct, the successful enrollment of the entire sample should cement the credibility of the study’s results. This could not have occurred without strong community participation, including our active collaboration with SIR Foundation and a public endorsement of the study by the US surgeon general,” Vedantham is quoted as saying the SIR Foundation announcement.
ATTRACT data could change guidelines
Vedantham spoke to Interventional News in September 2014 on the latest from the paper “Quality improvement guidelines for the treatment of lower-extremity deep vein thrombosis with use of endovascular thrombus removal” after its online publication in the Journal of Vascular and Interventional Radiology (JVIR) to say: “This article represents the best consensus quality improvement tool we could develop within the bounds of existing catheter-directed thrombolysis studies, which are still quite limited in scope and methodology. We hope and expect that the next version of these guidelines will be created with the benefit of additional randomised trial data, including that from the National Institute for Health-sponsored, multicentre, randomised, assessor-blinded, ATTRACT (Acute venous thrombosis: thrombus removal with adjunctive catheter-directed thrombolysis) trial.”