Vascular and interventional cardiology experts including Kim Hodgson (Springfield, USA), Ramon Varcoe (Sydney, Australia) and Gary Ansel (Columbus, USA) give their thoughts on the recently released meta-analysis in JVIR, which has suggested an increased risk of death or amputation at 12 months when paclitaxel-coated balloons are used in the infrapopliteal arteries for the treatment of critical-limb threatening ischaemia (CLTI).