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Evaluation of transpulmonary chemoembolization (TPCE)
The incidence of lung cancer has increased considerably in the last few decades with the lung as the most common site of metastatic involvement....
Conventional transarterial chemoembolization more cost-effective than drug-eluting embolic TACE
Compared with doxorubicin-loaded drug-eluting embolic transarterial chemoembolization (DEE-TACE), conventional transarterial chemoembolization (cTACE) yielded a higher number of quality-adjusted life years (QALY) at a lower...
Lipiodol—an effective imaging biomarker for chemoembolization of hepatocellular carcinoma
Beyond embolization endpoints under fluoroscopic guidance, the introduction and standardisation of cone-beam CT imaging in the procedure room has allowed Lipiodol (Guerbet) to become...
CIRSE launches Europe-wide study of transarterial chemoembolization with Terumo Lifepearl
The Cardiovascular and Interventional Radiological Society of Europe (CIRSE) has launched its CIRSE Registry for LifePearl Microspheres (CIREL), a new European-wide observational study that...
Sorafenib: A good candidate for hepatocellular carcinoma chemoembolization
By Alexandre Laurent, Laurent Bédouet and Laurence Moine
Chemoembolization with sorafenib (Bayer and Onyx Pharmaceuticals) is a promising technique for the treatment of hepatocellular carcinoma...
Understanding emulsions could help make the ideal cocktail for conventional transarterial chemoembolization
Considering the many advantages of conventional transarterial chemoembolization (cTACE) and its continued widespread use across the globe, we may want to try, one more...
Single agent chemoembolization scores over triple drug version for liver cancer
Research presented in February at the Symposium on Clinical Interventional Oncology (CIO), held in conjunction with International Symposium on Endovascular Therapy (ISET), in Hollywood, USA, provides a clear shot in the arm for chemoembolization that uses doxorubicin and ethiodised oil over the triple-drug version.
Drug-eluting beads loaded with anti-angiogenic agents for chemoembolization
While emphasising the interesting findings from their laboratory for interventional radiologists, Olivier Jordan and Katrin Fuchs write that laboratory benches not only give birth to inventions with a potential for translation into clinics, but also contribute to unbiased characterisation of products already in clinical use.
Transarterial chemoembolization using BRMS
This video visually explains the process for transarterial chemoembolization (TACE) using bioresorbable microspheres, a new type of embolic agent that is being tested in...
New directions for transarterial chemoembolization
There are many new directions for research in the field of transarterial chemoembolization (TACE). After the key development of drug-eluting beads, a better understanding of the cellular mechanisms of TACE is mandatory to take the procedure further, writes Alban Denys.
Increased risk of hepatotoxicity in transarterial chemoembolization patients with poor hepatic reserve
David N Tran, UCSF, San Francisco, USA, spoke on the topic of chemoembolization at the Society of Interventional Radiology‰Ûªs Annual Meeting (13‰öÕ18 April 2013, New Orleans, USA), he discussed transcatheter arterial chemoembolization in liver transplant candidates with and without marginal hepatic reserve.
Sirtex Medical announces Magle Group EmboCept S collaboration agreement
Sirtex Medical, a leading manufacturer of interventional treatment solutions, has announced the establishment of a collaboration and exclusive worldwide distribution agreement with Magle Group,...
New renal technologies: From radial access to angio-CT
Olivier Pellerin (Université de Paris, Paris, France) presented on technological updates in the renal space at the Global Embolization Oncology Symposium Technologies meeting (GEST;...
Instylla announces completion of financing round
Instylla, a company developing next-generation liquid embolics for peripheral vascular embolotherapy, today announced the closing of a US$30 million financing round.
This financing round...
Pooled analysis data from 580 patients with unresectable HCC reinforce positive outcomes of LifePearl...
This advertorial is sponsored by Terumo Interventional Systems
LifePearl™ microspheres (Terumo) are polyethylene glycol (PEG) embolization microspheres that can be loaded with chemotherapeutic drugs including...
IO of the past, present and future: presentation predicts what is to come in...
Setting the audiences sights on the horizon at the 2023 Global Embolization Oncology Symposium (GEST, 18–21 May, New York City, USA) yesterday, Daniel Sze...
Speakers shine light on current evidence for the ‘IOs’ and the gaps therein
Two of the sessions from day one of the 2023 European Conference on Interventional Oncology (ECIO; 16–19 April, Stockholm, Sweden) drew delegates’ focus to...
All is not equal where US IR procedure access is concerned
Nima Kokabi (Emory Healthcare, Atlanta, USA) addressed the “uncomfortable truth” of healthcare disparities in the USA specifically within interventional radiology (IR) in a presentation...
PAIRS 2023: What the BCLC guidelines have omitted
Sarah White (Medical College of Wisconsin, Milwaukee, USA) opened the liver interventional oncology (IO) session at the Pan Arab Interventional Radiology Society (PAIRS) annual...
INSPIRE initiative seeks to standardise cTACE across the world
Thierry De Baère (Gustave Roussy; Villejuif, France) talks to Interventional News about the rationale behind setting up the Initiative on Superselective Conventional Transarterial Chemoembolization (INSPIRE), which...
HKUMed discovers new trimodality therapy for locally advanced liver cancer
A phase II clinical study on a trimodality therapy (START-FIT), conducted by the Departments of Surgery and Clinical Oncology, School of Clinical Medicine, University...
An insight into treating liver tumours with thermal ablation
Amanda Smolock (Medical College of Wisconsin, Milwaukee, USA) discusses how her practice operates, using microwave ablation nearly exclusively for primary and metastatic liver tumours...
“An important pillar of tumour treatment”: Degradable starch microspheres accepted by European guidelines
This advertorial is sponsored by PharmaCept.
The Cardiovascular and Interventional Radiological Society of Europe (CIRSE) recently incorporated transarterial chemoembolization with degradable starch microspheres (DSM-TACE) into...
Alban Denys
Alban Denys is a French-Swiss interventional radiologist who was one of the founding members of the Society of Interventional Oncology (SIO). He has held...
New embolic device demonstrates superior vessel filling in tumour models
Fluidx Medical disclosed study results examining extent of vessel filling using the GPX embolic device compared to microspheres, a common treatment for many types...
Yasuaki Arai
“I do not want interventional radiology to be a treatment for the rich, nor for those who live in the wealthiest countries.” Yasuaki Arai...
(Re)defining curative intent for HCC
Global Embolization Oncology Symposium Technologies (GEST; 19–22 May, New York, USA) provided delegates and faculty alike with the opportunity to hear about worldwide approaches...
Key tips and tricks to achieve best outcomes with Occlusafe™
NOTE: This video is ONLY available to watch in selected countries and geographies
The “ideal patient” for a balloon-occluded transcatheter arterial chemoembolization (B-TACE) procedure...
Occlusafe™-TACE improves response and reduces retreatment in HCC patients
NOTE: This video is ONLY available to watch in selected countries and geographies
Thierry De Baere (Villejuif, France) talks to Interventional News about the...
International training and outreach in the pandemic era
As we start to emerge from the strictures imposed by the COVID-19 pandemic, it is timely to reflect on the delivery of education and...
Interventional News’ top 10 most popular stories for June 2021
June 2021 saw the publication of issue 82 of Interventional News, and both our cover stories were amongst those most widely-read on our site...
Degradable starch microspheres offer greater flexibility with TACE, enabling whole-liver embolization
This advertorial is sponsored by PharmaCept.
Andreas H Mahnken (Clinic of Diagnostic and Interventional Radiology, Marburg University, Marburg, Germany) enthuses to Interventional News about the...
HEPAR Primary study demonstrates safety of 166Ho-radioembolization in HCC, lays foundation for individualised cancer...
This article is sponsored by Terumo Interventional Systems.
Holmium-166 (166Ho) radioembolization is a safe treatment option for patients with hepatocellular carcinoma (HCC), show results from...
COLDFIRE 2: IRE is safe, effective in patients unsuitable for thermal ablation or surgery
Irreversible electroporation (IRE) is an effective and relatively safe treatment for colorectal liver metastases 5cm or smaller that are deemed unsuitable for partial hepatectomy,...
First patients enrolled in the Embrace hydrogel embolic system global randomised multi-centre clinical trial
The initial patients have been enrolled in the Embrace hydrogel embolic system (HES) global randomised clinical trial for the treatment of hypervascular tumours, Instylla...
Prior ablation therapy predictor of increased Y-90 uptake: The road to personalised dosimetry at...
Delineating the path towards personalised dosimetry in order to “maximise response to therapy”, David McNiel (University of Arizona Health Sciences, Tucson, USA) presented clinical...
Boston Scientific receives FDA approval for TheraSphere Y-90 glass microspheres
The US Food and Drug Administration (FDA) have granted approval of the TheraSphere Y-90 glass microspheres (Boston Scientific), developed for the treatment of patients...
TACE with drug-eluting microspheres as “safe and effective” as conventional TACE, pooled analysis shows
The sustained release of anthracyclines and durable embolization from LifePearl microspheres (Terumo Europe) makes transarterial chemoembolization (TACE) with these embolic agents a safe and...
Artificial intelligence should be incorporated into interventional oncology curricula to advance the specialty, BSIR...
“Artificial intelligence is changing the face of healthcare for all stakeholders, from consumers to providers,” Stephen Hunt (University of Pennsylvania, Philadelphia, USA; co-founder...
Cancer treatment beyond systemic chemotherapy: Local intra-tumoural injections demonstrate abscopal effect
Preclinical and clinical studies show that local, intra-tumoural injection of immunomodulatory agents can result in the shrinking of tumours distant from the site of...
Radioembolization with Y-90 now “a versatile treatment option” for HCC patients of all stages
As presented at the Global Embolization Oncology Symposium Technologies (GEST) 2020 meeting (4–6 September, virtual), Robert Lewandowski discusses the evolution of radioembolization with Yttrium-90...
Combination of immuno-oncology and liver-directed therapy: Where do we stand?
Ushering in “the era of IO”, Brad Wood calls for interventional oncologists to learn the language of immuno-oncology—“the other IO”—in order to improve care...
Bill Rilling
Instrumental to the development of interventional oncology in the USA and globally, William (Bill) Rilling tracks how the discipline has grown over the course...
The first virtual CIRSE: What you need to know
Ahead of the first ever virtual meeting of the Cardiovascular and Interventional Radiological Society of Europe (CIRSE), Thomas Kröncke, chairperson of the CIRSE 2020...
Radioembolization paper publication a “landmark moment” for IR-Hepatology collaboration
The cover of June’s edition of the Journal of Hepatology featured a paper on transarterial radioembolization for the treatment of hepatocellular carcinoma (HCC). Publication...
Lipidol Ultra-Fluid recevies approval for use in cTACE by China NMPA
Guerbet has announced the approval of an additional indication for Lipiodol Ultra-Fluid by the China NMPA (National Medical Products Administration) for use in transarterial...
Vectorio approved in Canada, an innovative medical device for interventional oncology procedures
Guerbet has announced the registration of Vectorio, a kit for imaging hepatocellular carcinoma (HCC), in Canada.
The kit consists of a set of Lipiodol-resistant medical...
Coalition of cTACE and immunotherapy: Expanding the horizons of interventional oncology
This article is sponsored by Guerbet. immunotherapy
Preliminary evidence suggests that combining conventional transarterial chemoembolization (cTACE) with immunotherapy could be beneficial to patients with unresectable...
CE mark granted to the first biodegradable drug-eluting microspheres, BioPearl
Terumo Europe today announced that their BioPearl microspheres have received CE mark, providing a new option for patients eligible for locoregional embolization for the...
Matthew Johnson
Inspired by his father, an interventional radiologist who used to shape catheters over the stove at home, Matthew Johnson switched from a residency in...
SeQure® microcatheter could help to make embolisation more secure
NOTE: This video is ONLY available to watch in selected countries and geographies
Geert Maleux (Leuven, Belgium), one of the first users of the SeQure®...
Movie magic: The power of distraction
The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, UK, has become the first in the country to offer patients audio-visual goggles to...
TriNav receives CMS approval for transitional pass-through payment status
TriSalus Life Sciences (formerly Surefire Medical) has announced that the Centers for Medicare and Medicaid Services (CMS) granted approval for transitional pass-through (TPT) payment...
Ricardo García-Mónaco
Establishing the first Interventional Radiology department in Argentina, Ricardo García-Mónaco is a pioneer of minimally invasive, image-guided therapies in South America. Looking back on...
International collaboration has fuelled a decade of development for IR in Myanmar
Collaboration, academic support, and hands-on training provided by the Singapore General Hospital, Singapore, have driven the small interventional radiology (IR) community of Myanmar to...
A glimpse of the future: The next decade of interventional innovations
Interventional News speaks with Atul Gupta about the future of interventional radiology (IR). As a chief medical officer for Image-Guided Therapy, Philips, he enthuses...
Interventional radiology TED talk raises awareness of image-guided, minimally invasive medicine
Oleksandra Kutsenko, a radiology resident at Upstate Medical University, Syracuse, USA, and Society of Interventional Radiology-Resident Fellow Student (SIR-RFS) advocacy chair, has given a...
Nanotechnology answers outstanding clinical questions in interventional oncology
“Interventional radiology is uniquely equipped to shape the next generation of nanotherapeutics,” Sarah White, associate professor of Radiation and Surgical Oncology at the Medical...
Automatic characterisation of Lipiodol deposition after cTACE may make predictions about tumour response
Automatic characterisation of Lipiodol (Guerbet) deposition is feasible, workflow efficient, and improves consistency across patients, argued Sophie Stark (Yale School of Medicine, New Haven,...
Society of Interventional Oncology requests updates to NCCN guidelines to more strongly recommend ablation
The Society of Interventional Oncology (SIO) is working more closely within cooperative groups and taskforces, as well as amongst the guidelines commentariat, to provide...
A call to arms against “the tyranny of the randomised controlled trial”
“Arm yourself with the comprehensive but nuanced science behind hepatocellular carcinoma (HCC),” Riad Salem (Northwestern Memorial Hospital, Chicago, USA) instructed the audience at the...
Ablation cheaper than Y-90 or TACE for the treatment of hepatocellular carcinoma
Ablation costs are significantly less than those of transarterial chemoembolization (TACE) and Yttrium-90 (Y-90), according to a comparative cost analysis of the three...
ET 2019: New data support TACE using microspheres in both HCC and colorectal cancer
Transarterial chemoembolization using microspheres appears to show “much better outcomes” than those seen with conventional TACE, both in the setting of hepatocellular carcinoma (HCC)...
Alex Tang
“Deep in my heart, I knew interventional radiology (IR) had a tremendous future,” Alex Tang tells Interventional News. Looking back at his career, Tang...
New indication approved for Guerbet’s Lipiodol Ultra Fluid
A new indication for Lipiodol Ultra Fluid (Guerbet) has been approved in Switzerland and in India for chemoembolization (cTACE) of tumours in adults with...
Embolx extends the sniper balloon occlusion microcatheter family with launch of new K-tip design
Embolx has announced the commercial availability of the new Sniper K-tip in the USA and Europe. The sniper balloon occlusion family of microcatheters now...
Call for IRs to standardise reporting of procedures to aid HCC patient outcome predictions
The lessons learned from a recent research article were outlined in a presentation by interventional radiologist Maxime Ronot (Beaujon University Hospital, Paris, France) at...
Y-90 radioembolization in hepatocellular carcinoma: “Liver function is key”
Jens Ricke (Department of Radiology, University Hospital LMU Munich, Germany) presented the latest evidence about Y-90 radioembolization in hepatocellular carcinoma (HCC) at the 2019...
In memoriam—Professor João Bexiga Martins Pisco (1941–2019)
Tiago Bilhim remembers Professor João Bexiga Martins Pisco, who passed away on 26 March 2019, during the annual meeting of the Society of Interventional...
Laura Findeiss
After coming across interventional radiology in a “fortunate accident”, the 2019–2020 Society of Interventional Radiology (SIR) president Laura Findeiss talks to Interventional News about...
Adding cryoablation to sorafenib improves the efficacy of renal cell carcinoma treatment
Cryoablation increases the clinical efficacy of treatment with the oral multi-target antitumour drug sorafenib for advanced renal cell carcinoma (RCC), a new study published...
Success of stereotactic radiofrequency ablation in larger tumours “challenges resection as first-line treatment”
According to recent research from Reto Bale and colleagues, multi-probe stereotactic radiofrequency ablation with intraprocedural image fusion represents an efficient invasive therapy for hepatocellular...
Stereotactic radiofrequency ablation is effective even in tumours over 3cm, study finds
Multi-probe stereotactic radiofrequency ablation (SRFA) with intraprocedural image fusion represents an efficient minimally invasive therapy for hepatocellular carcinoma (HCC), even with tumour sizes larger...
Top trends in ablation in 2018
Roberto Iezzi provides an overview of ablative therapies, and what interventional radiologists can expect from ablation procedures in the near future. Amongst the emerging...
Flowing on the horizon: Liquid embolics in development
To become a mainstay liquid embolic for peripheral use, an optimal product should be easy to use, have reproducible and controllable deep penetration for...
Vectorio®: Efficacy and safety for improved cTACE mixing and delivery
This educational supplement, sponsored by Guerbet, is intended for readers in the EU only. Guerbet obtained the CE mark for its conventional transarterial chemoembolization...
Stephen B Solomon
Stephen B Solomon, chief, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, New York, USA and president of the Society for Interventional Oncology (SIO)...
Artificial intelligence will support clinical decision making in interventional oncology
Aaron Abajian and Julius Chapiro, New Haven, USA, write about results from an early experiment in applying artificial intelligence (AI) and machine learning as a...
New data demonstrate clinical experience with LifePearl microspheres in over 300 hepatocellular carcinoma patients
Transarterial chemoembolization (TACE) using LifePearl (Terumo) drug-eluting embolic agents in the treatment of hepatocellular carcinoma has just been published.
International survey reveals high variability in TACE technique
Transarterial chemoembolization (TACE) is a mainstay of locoregional treatment for hepatocellular carcinoma (HCC) in the intermediate stage. “The technique for this procedure, however, continues...
Guerbet launches two new microcatheters for use in embolization procedures
Guerbet has announced the upcoming launch of SeQure and DraKon, two novel microcatheters for tumour and vascular aneurysm embolization procedures. The company introduced the...
Radiation segmentectomy offers new treatment option for liver cancer
Radiation segmentectomy is a minimally invasive option that uses the radioisotope yttrium-90 (Y90) to destroy tumours. One-, three-, and five-year overall survival probability was 100%, 82% and 75% in patients with a baseline tumour size of 3cm or less.
Guerbet acquires Occlugel and new microsphere technology for initial €3 million payment
Guerbet has announced that it has signed an agreement to acquire a laboratory-stage technology developed by Occlugel, a French company specialised in the research...
SIRT fails to extend survival in the SORAMIC study palliative cohort
The SORAMIC study, presented at The International Liver Congress, shows that the addition of selective internal radiation therapy (SIRT) to sorafenib in patients with...
Guerbet announces Lausanne partnership to evaluate immunogenic potential of cTACE
Guerbet has announced a partnership with the Department of Radiodiagnosis and Interventional Radiology of Lausanne's University Hospital (CHUV) and the Lausanne Center for Experimental...
First patient enrolled in CIREL, a Europe-wide observational study on TACE with Lifepearl
The Cardiovascular and Interventional Radiological Society of Europe (CIRSE) announced that the first patient has been enrolled in CIREL (CIRSE registry for LifePearl microspheres),...
Terumo Europe NV announces approval of LifePearl as a Class III device in Europe
This approval also expands the number of chemotherapeutic drugs that can be loaded onto LifePearl to include idarubicin and epirubicin, a press release from...
Future directions for ablation in interventional oncology
The notion of locally destroying a cancer percutaneously with minimal morbidity and mortality has become accepted as part of the modern armamentarium for treating...
Persistence, persistence, persistence: Lessons in device innovation from three prolific inventors
Timothy Clark, director of Interventional Radiology at Penn Presbyterian Medical Center, Philadelphia, USA and co-founder and chief executive officer of Forge Medical, which has...
First patient treated with vandetanib-eluting beads that are visible on CT scans
Researchers from the University College London (UCL) Cancer Institute, London, UK, and BTG have begun the first clinical trial of an experimental treatment for...
Vast majority of patients prefer radial access for embolization therapies in liver cancer
“While both radial and femoral accesses are safe and effective for transarterial liver embolization, it is clear that the patients prefer radial access,” said Marcelo Guimaraes, Charleston, USA, who was presenting on the...
Guerbet announces CE mark for Vectorio mixing and injection system for cTACE procedures
Guerbet has announced obtaining the CE mark for its conventional transarterial chemoembolization (cTACE) mixing and injection system, Vectorio.
Designed in collaboration with interventional radiologists worldwide,...
Mentice aims to reduce TACE procedure times and radiation exposure with new simulation software
Mentice has announced the release of a new simulation training software for transarterial chemoembolization (TACE). The new software was showcased at the 2017 CIRSE...
Y-90 experience in HCC crosses 1,000-patient milestone
“We are most enthusiastic about the use of radioembolization to treat patients with early stage Barcelona Clinic Liver Cancer (BCLC) A disease. The long time...
Dexamethasone treatment prevents TACE side-effects in hepatocellular carcinoma patients
A randomised, double-blind, placebo-controlled trial evaluating the efficacy of prophylactic dexamethasone in preventing the most frequent adverse events of transcatheter arterial chemoembolization (TACE) in...
Same day Y-90 treatment could become paradigm of the future
While further refining where radioembolization should optimally lie in current treatment paradigms for the most common liver-confined or liver-dominant cancers is important, a honing...
Peer-reviewed medical journals should publish scientifically valid information “to combat misinformation”
Klaus Hausegger, chairman of the Institute of Diagnostic and Interventional Radiology in Klagenfurt, Austria, and president-elect of the Austrian Roentgen Society, will take up a new...
WCIO session highlights the pick of recent interventional oncology research
A session at the World Conference on Interventional Oncology (WCIO; 8–11 June, Boston, USA), organised by the Society of Interventional Oncology (SIO), identified the...
SIRT significantly better tolerated than sorafenib, but does not increase overall survival in hepatocellular...
The 459-patient randomised controlled SARAH study shows that local treatments of advanced or inoperable hepatocellular carcinoma with selective internal radiation therapy (SIRT) did not...
First European patients treated with DC Bead Lumi radiopaque drug-eluting beads
Two patients were treated for hepatocellular carcinoma and one patient was treated for malignant colorectal cancer metastasised to the liver.
DC Bead Lumi is...
MIRACLE I demonstrates high tumour control rate for drug-eluting microspheres
Goetz Richter, Clinic for Diagnostic and Interventional Radiology, Stuttgart, Germany, presented breaking data from the Miracle 1 multicentre hepatocellular carcinoma trial at The Symposium...
Siemens Healthineers introduces innovations in ultrasound guidance and liver embolization
The new Acuson Freestyle Elite ultrasound system can now be combined with the Artis angiography systems to enable fast and easy-to-use ultrasound guidance during...
BTG receives CE mark for DC Bead Lumi
BTG has received Class III CE mark certification for DC Bead Lumi, the first commercially available radiopaque drug-eluting bead (DEB) in the EU which...
The role of Y-90 radioembolization for cholangiocarcinoma
Y-90 radioembolization is a promising locoregional therapy for a devastating disease with few available treatment options. Ongoing and future clinical trials will help to...
Using Y-90 to achieve bariatric artery radioembolization
Nearly 10 years have passed since Aravind Arepally et al published data from the first gastric artery chemoembolization preclinical trials for the treatment of...
Thailand FDA approves new indication for Guerbet’s Lipiodol Ultra-Fluide
Guerbet has announced that the Thailand FDA has given approval of a new indication for Lipiodol Ultra-Fluide for selective hepatic intra-arterial injection for visualisation,...
Surefire closes US$12.8 million funding, to present new data at SIR
Surefire, the developer of site-specific delivery devices for the interventional oncology market, has announced the first closing of a US$12.8 M Series D financing...
Ringing in the radial revolution
There is an explosion of interest in transradial access within interventional radiology. With the twitterverse abuzz with hashtags such as #radialfirst and #transradial and...
Prevention and management of complications of Y-90 therapy
Most complications related to Y-90 therapy may be prevented or mitigated with appropriate patient selection, careful pretreatment planning, meticulous procedural technique, and optimisation of...
Interventional radiology participation grows at RSNA clinical trials “bootcamp”
The Radiological Society of North America (RSNA) held its 12th Clinical Trials Methodology Workshop 7–13 January in San Diego, USA. This programme offers intensive...
Canada first country to get DC Bead Lumi treatment for liver cancer patients
BTG International Canada has announced the commercial launch of DC Bead Lumi in Canada. The launch represents the first market commercialisation of DC Bead...
The ten commandments of liver ablation: Part I
For the upcoming MIOLive symposium, we had the idea of introducing a special “ten commandments” session for ablation, chemoembolization, and radioembolization, to create a...
SARAH and SIRveNIB investigators to undertake combined prospective meta-analysis
Liver cancer researchers from France and Singapore collaborate on a prospective meta-analysis of two studies of Y-90 resin microspheres vs. sorafenib in patients with...
ESMO releases new consensus guidelines on the management of metastatic colorectal cancer
European Society for Medical Oncology (ESMO) has released new consensus guidelines for the management of metastatic colorectal cancer that reflect an increasingly personalised approach...
BTG announces successful CE mark reclassification for DC Bead to class III based on...
BTG has announced that it has obtained CE mark from the Notified Body British Standards Institution (BSI) following completion of the reclassification of DC...
Interventional News Issue 62 – June 2016
Highlights: -Immunotherapy could transform systemic power of locoregional IO treatments -Randomised data favour Y-90 therapy over conventional chemoembolization in patients with unresectable hepatocellular carcinoma...
Immunotherapy could transform systemic power of locoregional IO treatments
Many physicians now believe that immunotherapy is a disruptive field in cancer medicine. Interventional oncology can either “snooze and lose” as one prominent interventional...
Immunoembolization for treatment of metastatic uveal melanoma
Immunoembolization was developed for the treatment of this disease in hopes of both providing local control for the hepatic metastases and delaying onset of...
Embolotherapy course gains widespread interest as embolization “still underused” in Latin America
The 6th annual Embolotherapy Course was held in Buenos Aires, Argentina, in November 2015 with a high attendance from Latin American interventional radiologists. The...
Revolutionary new tool can achieve real-time, in vivo visualisation of tissue for biopsy
What if physicians could perform an optical biopsy? Further, what if during a cryoablation procedure, an interventional radiologist can actually see what happens during the procedure at a cellular level in real time? A new tool, Cellvizio (Mauna Kea) does just that.
Interventional radiologists as the new “virus whisperers”
Oncolytic immunotherapy or virotherapy is not a threat to interventional oncology—on the contrary it is a “huge and urgent” opportunity, said Daniel Sze while...
Randomised data favour Y-90 over TACE in patients with unresectable hepatocellular carcinoma
The results from a small prospective, randomised single-centre trial, the PREMIERE trial, show that in patients with unresectable hepatocellular carcinoma, there is a significantly longer time to progression with yttrium-90 (Y-90) radioembolization than with conventional transarterial chemoembolization (cTACE).
NICE Medtech briefing acknowledges consideration of SIR Y-90 resin microspheres as alternative to standard...
The UK National Institute for Health and Care Excellence (NICE) has issued a new Medtech Innovation Briefing stating that National Health Service doctors and commissioners may consider SIR-Spheres Y-90 resin microspheres as an alternative to standard therapy with transarterial chemoembolization or sorafenib in the treatment of patients with inoperable primary liver cancer.
SORAMIC study completes palliative cohort enrolment
Jens Ricke, professor of Radiology at the University of Magdeburg, has announced that the palliative cohort of the pan-European SORAMIC study he co-directs with Peter Malfertheiner has reached its enrolment target of 420 patients with unresectable hepatocellular carcinoma.
First procedure completed using the Hansen Magellan robotic catheter eKit
The device was used as part of a robotic transarterial chemoembolization procedure, which was completed by Ripal Gandhi at Miami Cardiac & Vascular Institute, Miami, USA.
Study challenges use of doxorubicin-eluting beads in hepatocellular carcinoma embolization
The final results from a phase 2 randomised trial, published online in the Journal of Clinical Oncology on 1 February, find no benefit from using doxorubicin-eluting beads (LC Bead, BTG) over embolic microspheres that do not elute a drug (Bead Block, BTG).
Radial access “safe and well tolerated” across range of peripheral vascular interventions
A single-centre, retrospective study published online in December 2015 in the Journal of Vascular and Interventional Radiology (JVIR), set out to review the safety...
BTG receives 510(k) clearance for novel radiopaque embolic bead, LC Bead Lumi
Early research on a simple method to produce radiopaque drug-eluting microspheres that can be incorporated into the current clinical transcatheter arterial chemoembolization workflow has also been reported.
Live webinar on radial access in interventional radiology
Darren Klass, Vancouver, Canada, is scheduled to lead a live webinar titled ‰ÛÏWhy radial for interventional radiologists‰Û on 11 January 2016 at 1300hrs Eastern Standard Time.
A trend towards resorbable microspheres
Jafar Golzarian, a professor of interventional radiology, University of Minnesota, Minneapolis, USA, founded EmboMedics in 2012 and serves as its chief medical officer. He tells Interventional News about the factors driving an interest in resorbable embolics.
Assessing tumour response after embolization in cancer
Assessment of tumour response with imaging-based tumour-specific response criteria is a crucial step to identify the value of a new therapy and to help clinicians to predict the prognosis of an individual patient, writes Christoph Zech.
CIRSE launches Europe-wide registry to study irinotecan-loaded LifePearl microspheres
A new European‰Ûwide observational study to prospectively gather data on patients treated with irinotecan‰Ûloaded microspheres has been launched by the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). The CIRSE Registry for LifePearl microspheres (CIREL) will begin early in 2016.
Surefire gets FDA nod for Precision direct-to-tumour embolization device
The infusion technology‰Ûªs unique expandable tip increases drug delivery into the tumour while protecting healthy tissue.
Experts point to size threshold below which drug-eluting embolics lose optimum embolic effect
While there is a trend towards using smaller sized particles to obtain better results with embolization, experts at the Global Embolization Symposium and Technologies (GEST EU) agreed that there appeared to be a lower size limit, <100åµm, below which drug-eluting beads did not have an effective embolic effect.
Terumo announces CE mark approvals for Lifepearl and Hydropearl microspheres
Terumo has announced that on 16 March 2015 it received CE mark for LifePearl, a new drug-eluting microsphere for chemoembolization and HydroPearl, a new microsphere for more predictable bland embolization.
Revolutionary focused ultrasound still needs to address limitations
Alessandro Napoli writes that therapeutic ultrasound still has some technological hurdles that need to be overcome, despite his success with the treatment over the past five years.
The challenges of measuring response in interventional oncology
An overview of three treatments: ablation, chemoembolization and selective interval radiation therapy, should clarify the challenges of determining tumour response in interventional oncology, write Maxime Ronot and Val̩rie Vilgrain.
Transradial access ‰ÛÏsafe and well-tolerated‰Û in typical IR patient population
A single-centre review of the safety and feasibility of using the transradial approach for peripheral and visceral interventions after the first 1,000 procedures finds that this access has extremely low complication rates.
First procedure with Magellan Robotic System in Australia announced
Hansen has announced the completion of the first clinical procedure with the Magellan robotic system in Australia.
Survey shows nearly 60% of UK centres perform TACE with drug-eluting beads
The results of a web-based survey designed to shed light on the practice of transarterial chemoembolization (TACE) in the UK have shown that there is a wide variation in practice with some centres using conventional TACE (with lipiodol and doxorubicin) and others using, newer drug-eluting beads.
Gao-Jun Teng
In the future, will interventional radiology be a subspecialty of radiology, or surgery? asks Gao-Jun Teng, professor of Radiology, Zhongda Hospital, Southeast University, Nanjing,...
Selective transarterial chemo embolization in lung cancer
Embolization therapy combined with infusion of antineoplastic agents offers considerable improvement of symptoms for patients, with far fewer complications than systemic chemotherapy, writes Shinichi Hori, Osaka, Japan.
Society of Interventional Radiology issues global call for research
The Society of Interventional Radiology (SIR) has issued a global call for scientific abstracts covering all areas of vascular and nonvascular interventional radiology for its 40th Annual Scientific Meeting, which will be held 28 February‰ÛÒ5 March at the Georgia World Congress Center in Atlanta, USA.
The microenvironment of solid tumours matters
By Aravind Arepally
Despite the rapid growth of imaging and treatment options in interventional oncology, one area that has been poorly understood and overlooked by...
EmboCoh visceral aneurysm cohort registry idea outlined at GEST US 2014
EmboCoh is a structured international web-based channel, designed so that physicians can enter their data on embolization procedures. It will enable collaborative registry-style data collection and analysis, particularly of uncommon embolization procedures, which would not be meaningfully possible from single-centre data due to the paucity of cases.
Pressure-directed embolotherapy using antireflux devices to perform liver directed regional therapy
By Steven C Rose
The evidence supporting the use of transarterial chemoembolization (TACE) and Yttrium-90 transarterial radioembolization (TARE) to treat primary and secondary liver malignancies...
Interventional radiology techniques and results for the management of neuroendocrine liver metastases
Interventional radiology techniques are widely performed and useful in liver metastases from neuroendocrine tumours, but the level of scientific proof is paradoxically low, especially...
First clinical cases with new Magellan 6F robotic catheter announced
The initial clinical experience is to be presented at the Global Embolization Symposium and Technologies US meeting (GEST US,1‰ÛÒ4 May, San Francisco, USA), a press release says.
COSY trial shows highly reduced radioembolization procedure time and radiation dose
Surefire Medical has announced that the COSY clinical trial (Coiling vs. Surefire infusion system in Y90) showed significant reductions in fluoroscopy time, procedure time,...
Launch of Hepatic Oncology: a journal dedicated to the management of cancers of the...
Hepatic Oncology is published by Future Medicine Ltd, and joins its portfolio of oncology journals providing healthcare practitioners and research professionals with a unique...
Interventional oncologists begin running US National Cancer Institute cooperative group trial
An important opportunity has opened up for interventional oncologists as WCIO leaders take the helm of the E1208 trial. Michael C Soulen writes that...
Francisco Cesar Carnevale
Francisco Cesar Carnevale tells Interventional News why prostatic artery embolization is an amazing procedure and why more needs to be done for paediatric interventional...
Surefire Medical completes patient enrolment in COSY trial
The trial evaluates eliminating coiling by using the anti-reflux Surefire Infusion System in radioembolization procedures in liver cancer.
Surefire Medical has announced that it has...
Personalised oncology is here to stay
A review, published in the Journal of Vascular and Interventional Radiology (JVIR) in August 2013, serves as an introduction to personalised oncology concepts and provides a summary of relevant concepts. Nadine Abi-Jaoudeh, lead author on the paper spoke to Interventional News about the implications for interventional radiologists.
Society of Interventional Radiology issues global call for scientific abstracts
It is now possible for members and non-members to submit abstracts online for the Society of Interventional Radiology‰Ûªs (SIR‰Ûªs) annual scientific meeting, to be held 22‰ÛÒ27 March 2014 in San Diego, USA.
Benefits of thermal ablation in the lung in conjunction with other therapies “cannot be...
Thomas Vogl, Institute of Diagnostic and Interventional Radiology, Goethe University, Frankfurt, spoke at ECIO (19–22 June, Budapest Hungary) about novel lung ablative techniques and...
Older liver cancer patients respond to radioembolization as well as younger patients, study says
Data from the multicentre ENRY evaluation of 325 patients, suggest that radioembolization may be a well tolerated and effective option for an increasing population...
SARAH study enroling patients throughout France for the treatment of primary liver cancer
Launched by the Assistance Publique Hôpitaux de Paris, France, in December 2011, SARAH (Sorafenib versus radioembolization in advanced hepatocellular carcinoma), a French national collaborative randomised controlled trial...
Doxorubicin-eluting microspheres limit progression of hepatocellular carcinoma
Investigators from Thomas Jefferson University published a study in the February edition of the Journal of Vascular and Interventional Radiology comparing the incidence of progression of hepatocellular carcinoma when treated with either doxorubicin-eluting beads or ethiodol-based regimens using either cisplatin/adriamycin/mitomycin-c (CAM) or adriamycin alone. Daniel B Brown writes about the outcomes and implications of this study.
Surefire Medical infusion system can prevent embolics entering non-target vessels for the treatment of...
Surefire Medical’s new infusion system maximises delivery of drugs directly to the tumour site while minimising potential damage to non-target organs, according to a...
TACE procedure in Japan and Korea was favourable for overall survival in hepatocellular carcinoma...
A study led by Masafumi Ikeda, National Cancer Center Hospita, Kashiwanoha, Kashiwa Chiba, Japan, and published in the Journal of Vascular and Interventional Radiology,...
Chuck Ray
Chuck Ray is a professor and vice-chair of radiology at University of Colorado, Colorado, USA. He has served as a Lieutenant Colonel in the...
Surefire Medical receive the CE mark for its infusion system and specialty catheters
The Surefire Infusion System ST/LT and the Surefire Specialty Catheters have received the CE mark and regulatory approval in New Zealand where distribution will begin, according to the company. The infusion system and catheters have received US FDA approval.
Lower rates of post-embolization syndrome and fatigue with smaller drug-eluting beads for hepatocellular carcinoma
Siddharth A Padia, University of Washington Medical Center, Seattle, USA, and colleagues, stated that, although transarterial chemoembolization is a standard treatment for hepatocellular carcinoma,...
Nordion to host educational symposium at the Gastrointestinal Cancers Symposium 2013
The agenda at the Gastrointestinal Cancers Symposium, San Francisco, California, USA, includes new hepatocellular carcinoma clinical data and an update on TheraSphere Phase III clinical trials.
Transcatheter therapies for liver cancer: which ones are best and when?
Michael C Soulen professor of Radiology and Surgery at Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA, and chairman of the WCIO Board of Directors discusses the recurring theme of alternative embolotherapies for hepatic malignancies
IO-Central.org: The site for updates and discussions regarding interventional oncology
Daniel Brown, professor of Radiology, chair of the IO Central committee, describes the main features of IO-Central.org, a site designed to provide evidence-based content with real-time updates in interventional oncology.
Surefire Infusion System for embolization procedures receives CE mark approval
Surefire Medical has received CE mark approval for its Surefire Infusion System, a next generation device for chemo- and radioembolization procedures. The company has...
Surefire Medical receives FDA clearance for High-Flow Microcatheter
Surefire Medical has announced that it has received 510(k) FDA clearance to market the Surefire High-Flow Microcatheter, the next generation of the company’s novel...
“Both interventional radiologists and radiation oncologists would benefit from an alliance”
Adam, London, UK, who has been president of every major radiology and interventional radiology association in Europe, including CIRSE, the European Society of Radiology...
“It is important to pursue imaging response assessment”
Robert J Lewandowski, associate professor of Radiology, Northwestern University, Chicago, USA, who was part of the GEST 2012 US scientific programme committee, gave Interventional...
The benefits of radioembolization
At the European Conference on Interventional Oncology (ECIO) meets International Liver Cancer Association (ILCA) session in Florence, Bruno Sangro, Pamplona, Spain, spoke on the...
SPACE trial points to combination therapy as the key
The SPACE trial captures the potential synergy between TACE with drug-eluting beads and sorafenib, writes Riccardo Lencioni, Pisa, Italy.
IR faces ‰ÛÏring of fire‰Û: Call for improved clinical judgement and evidence
Jon Moss, Glasgow, UK, delivered the CIRSE 2011 Andreas Gruentzig lecture. He advocated greater clinical judgement and warned that there was a ‰ÛÏring of fire‰Û in interventional radiology with several procedures being carried out without strong evidence backing them.
Riccardo Lencioni
As a former football referee, Riccardo Lencioni tells Interventional News readers how important it is to respect the rules —how important it is to...
CCSVI remains controversial: SIR debate shows divergent views among interventionalists
An SIR session titled "The Sterile Gloves Are Off" featured a heated debate on the proposition "The level of evidence linking chronic cerebrospinal venous insuffiency (CCSVI) and multiple sclerosis is inadequate and the clinical benefits of endovascular treatment are suspect"
Proposed study for liver cancer previewed at interventional oncology meeting
Riccardo Lencioni, principal investigator, previews new liver cancer study hqTACE in a proposed international clinical trial currently under FDA review.
PRECISION V shows DC Bead is safer and effective for treatment of HCC
At the CIRSE meeting 2008, held in Copenhagen, Denmark, Professors Johannes Lammer, Anthony Watkinson, and Riccardo Lencioni presented new data supporting the use of Biocompatibles‰Ûª PRECISION TACE with DC Bead (DC Bead loaded with doxorubicin) for the treatment of hepatocellular carcinoma (HCC). The multi-centre study compared drug-eluting beads (DEB) with conventional transarterial chemoembolization (cTACE).
